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Physics Department Colloquium/Seminar

Schedule:

April 27, 2009
12 pm – 1pm, 408 FMH

Gleb Shtengel
Howard Hughes Medical Institute

Interferometric fluorescent super-resolution microscopy of 3D cellular ultrastructure

Understanding molecular-scale architecture of cells requires determination of 3D locations of specific proteins with accuracy matching their nanometer-length scale. We introduce interferometric photoactivated localization microscopy (iPALM), the combination of photoactivated localization microscopy with single-photon, simultaneous multiphase interferometry that provides sub-20-nm 3D protein localization with optimal molecular specificity.  We demonstrate measurement of the 25-nm microtubule diameter, resolve the dorsal and ventral plasma membranes, and visualize the arrangement of integrin receptors within endoplasmic reticulum and adhesion complexes, 3D protein organization previously resolved only by electron microscopy.  iPALM thus closes the gap between electron tomography and light microscopy, enabling both molecular specification and resolution of cellular nanoarchitecture.

Monday, April 6, 2009
12 pm - 1pm, 408 FMH.

Prof. Andrew Hill
Department of Biology, NJIT

The effect of prenatal nicotine exposure on postnatal development of the respiratory rhythm|

Nicotine in the form of maternal smoking and environmental tobacco smoke may represent the single most important neurotoxicant to affect fetal development.  The goal of this work is to understand how prenatal nicotine exposure affects the postnatal development of the respiratory rhythm.  Using an animal model, we will test the hypothesis that prenatal nicotine exposure leads to developmental defects of the serotonergic system of the brainstem, which may, in turn, affect the ability of the brainstem to respond appropriately with protective reflexes to changes in O2 and CO2 tension. 

Monday, March 30 from 12.30-1pm
408 FMH.   Please note the new time for this seminar

Prof. Mitra Shojania-Feizabadi
Physics Department, Seton Hall

Cancer Study from Modeling and Theoretical to the Experimental
During this talk, I will discuss the cancer study from three different perspectives.  I will start with modeling of a tumor interacting with anti-mitotic drugs.
Next, I will discuss the microtubules as a key component of cytoskeleton responsible for the cell division and its mechanism to find a chromosome as a
target to proceed the mitosis.  Lastly, I will discuss the importance of investigating the rigidity of microtubules in cancerous cells.

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